Editorial Expression of Concern: Opposing roles for calcineurin and ATF3 in squamous skin cancer

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Nature, Published online: 24 February 2026; doi:10.1038/d41586-026-00514-y

"[In] the 1960s [it] turned out, in hindsight, we had a near-endless schedule margin there," Isaacman said. "That is certainly not the case today. I'd say this is very, very close from a timeline perspective."

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What if you create a truly unique routing profile that's wildly different from the common ones for which shortcuts were pre-calculated? The system is smart. If it detects that too many shortcuts (~50, for example) need on-the-fly recalculation and deviate significantly, it might determine that falling back to the original, comprehensive A* algorithm for the entire route would actually be faster than doing many small, heavily modified A* calculations.

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